Toxicology
Innovation examples
HealthToxicologyIn silico
Predictive computer models for protein binding
In this video Linde Schoenmaker (Leiden University) explains how she and her colleagues are making computer models to predict the safety of new chemicals within the VHP4Safety project.
Innovation examples
HealthToxicologyIn vitro
Thyroid Hormone & Brain Development: animal-free models for human safety assessment
The environment can have a significant impact on a child's health even before birth. Brain development begins in the first trimester and continues until the age of 25, with thyroid hormone playing a critical role. During early pregnancy, the fetus depends on the mother's thyroid hormone, and a disruption in the thyroid hormone balance can lead to cognitive and motor impairments in the child. As part of the VHP4Safety project, we are developing in vitro tests to measure the developmental neurotoxic effects caused by disturbances thyroid hormone concentrations. Current testing guidelines do not always include testing for neurodevelopmental effects, highlighting the need for new non-animal methods. At the Erasmus Medical Center, human cell lines representing brain cell types are cultured to study the effect of chemicals on the thyroid hormone balance. RIVM uses human stem cells to create neuron-astrocyte networks that mimic brain development. By combining these different assays and models, we are creating a comprehensive human-based testing strategy to assess developmental neurotoxicity. These advances are a critical step toward eliminating animal testing while protecting the health and environment of future generations.
Projects and initiatives
HealthToxicologyIn vitro
RISKHUNT3R project – interview by TOXstreams
Many studies are focused on finding the next best tool or test to assess the risk associated with chemical exposure. That is all well and good, but even the perfect assay needs to be accepted by regulators before seeing the light of the day. And how do we do that? The guests in this webinar have some ideas on that as principal investigators of the EU project RISK HUNT3R. Prof. Bob van de Water, Dr Mirjam Luijten and Dr Andrew White explain what RISK HUNT3R is doing, what next generation risk assessment means and why it is so important. Click on the link in the video to watch the whole interview.
Expert interviews
HealthToxicology
Ecotoxicology explained - interview by TOXstreams
Toxicology is a complicated area where you have to figure out if a chemical is safe for the entire human population? Well, some researchers in this field go even beyond, and instead of studying the safety of substances on “just” people, they focus on any living being on the whole planet. In this TOXstreams interview ecotoxicologists Dr Adam Lillicrap from the Norwegian Institute for Water Research and Dr Kristin Schirmer from the Eawag Science and Technology and co-founder of aQuaTox Solutions GmbH Solutions will explain what and how they do this. Click on the link in the video to watch the whole interview.
Projects and initiatives
HealthToxicologyIn vitro
PrecisionTox project – interview by TOXstreams
What do nematodes, zooplanktons, clawed frogs, fruit flies, zebrafishes and humans have in common? Well, they are all part of the EU-funded project PrecisionTox. In this teaser for the TOXstreams interview, PrecisionTox researchers explain how they are combining non-traditional test species with molecular and computational methods to better protect our society from toxic chemicals. Prof. John Colbourne, the project’s coordinator, Dr Gaëlle Hayot, Christina Cramer von Clausbruch will tell all you want to know. Click on the link in the video to watch the whole interview.
Projects and initiatives
HealthToxicologyIn vitro
ONTOX project – interview by TOXstreams
Have you ever wondered how one can actually develop a new approach method (NAM) to replace animal testing in toxicology? The ONTOX project is creating not just one but six different NAMs. Indeed, this EU-funded project is focused on building NAMs to study repeated dose toxicity effects, an area of toxicology that still relies heavily on animal testing. Prof. Mathieu Vinken, the project’s coordinator, Jian Jiang, PhD, Anouk Verhoeven and Jonas van Ertvelde explain their work to TOXstreams. Click on the link in the video to watch the full episode.
Innovation examples
ToxicologyIn vitro
Combatting the worlds deadliest infections using groundbreaking human-mimetic tools
Combatting the worlds deadliest infections using groundbreaking human-mimetic tools.
Zika, dengue & other viruses are typically tested in monkeys & mice. But is using animals really the most effective way? Find out what Dr. David Pamies of the @jhucaat - along with his colleagues at @JohnsHopkins - are doing to upend the status quo.
More information on:
https://www.eurekalert.org/pub_releases/2019-06/hsi-ctw061319.php
and
https://www.frontiersin.org/articles/10.3389/fcimb.2019.00223/
Expert interviews
Toxicology
How do we use human data in risk assessment
In this video, EFSA explains how they do risk assessment and what the role of NAMs can be in this process.
Projects and initiatives
HealthToxicologyInnovationIn vitro
Cells4Thought: using iPSCs for neurodevelopmental health
The prevalence of neurodevelopmental disorders (NDDs), including cognitive impairments, is increasing worldwide with great impact on daily life quality. There is evidence that exposure to chemicals may contribute to the incidence of NDD. However, a causal link is lacking. Towards this goal, a human-relevant in vitro model system mimicking parts of brain development, such as neuronal network functioning, could be used for mechanistic research on how gene-environment interactions contribute to the development of NDD. This is going to be studied in the project Cells4Thought, using induced pluripotent stem cells form different individuals to study the effect of chemicals on neuronal differentiation.
Innovation examples
HealthToxicology
New approaches for cancer hazard assessment
Chemical substances are subjected to assessment of genotoxic and carcinogenic effects before being marketed to protect man and the environment from health risks. For cancer hazard assessment, the long-term rodent carcinogenicity study is the current mainstay for the detection of nongenotoxic carcinogens. However, carcinogenicity studies are shown to have prominent weaknesses and are subject to ethical and scientific debate. A transition toward a mechanism-based weight of evidence approach is considered a requirement to enhance the prediction of carcinogenic potential for chemicals. At RIVM, we are working on this alternative approach for cancer hazard assessment, which makes optimal use of innovative (computational) tools and be less animal demanding.
For more information, click on the link in the video or read on here (https://doi.org/10.1080/10408444.2020.1841732) and here (https://doi.org/10.1080/10408444.2018.1458818).
Contact the expert (https://nl.linkedin.com/in/mirjamluijten)
Meetings & conferences
HelpathonsHealthToxicologyIn silico
ONTOX Hackathon: Hack To Save Lives And Avoid Animal Suffering
Artificial Intelligence (AI) in toxicology – a potential driver for reducing or replacing laboratory animals in the future. ONTOX project is looking for solutions and innovative ideas to move forward. Are you going to help ONTOX to hack into these complex challenges?
The hackathon will be held from 21 to 23 April 2024 in Utrecht Science Park. The whole event is open to a diverse community of forward-thinkers and problem-solvers interested in the intersection of AI and ethical toxicology. The goal is to bring together passionate individuals who seek innovative solutions to critical challenges in toxicology.
Read more about the hackathon and register here (https://ontox-project.eu/hackathon/).
Innovation examples
HealthToxicologyInnovationIn vitro
Human based 3D liver models
Human-based in vitro models are increasingly being used in the hepatology field. And in addition to the obvious ethical arguments, they offer several advantages over the classical animal models. One of them is the ability to perform mechanistic research at the molecular level in a well-controlled setting and reduce species differences. These liver-based in vitro models can range from simple monolayer cultures of hepatocytes to the liver-on-chips systems in which all liver cells are cultured in a 3D configuration on a microfluidic platform. Liver-based in vitro models must be selected on a case-by-case basis and should fit the purpose of the research, which might go from fundamental to translational research.